{"id":27806,"date":"2016-11-07T15:39:13","date_gmt":"2016-11-07T23:39:13","guid":{"rendered":"https:\/\/cjnotebook.com\/?p=27806"},"modified":"2016-11-07T15:39:13","modified_gmt":"2016-11-07T23:39:13","slug":"medical-device-manufacturer-pays-more-than-36-million-for-misbranding","status":"publish","type":"post","link":"https:\/\/cjnotebook.com\/?p=27806","title":{"rendered":"Medical Manufacturer Pays More Than $36 Million for Misbranding Tumor Device"},"content":{"rendered":"

WASHINGTON D.C.<\/strong><\/span><\/p>\n

\n

\"criminal_justice_jurisprudenceA Pennsylvania-based medical device manufacturer Biocompatibles Inc., a subsidiary of BTG plc, plead guilty Monday to misbranding its embolic device LC Bead, federal authorities announced.<\/span><\/p>\n

Biocompatibles will pay more than $36 million to resolve criminal and civil liability arising out of its illegal conduct.<\/span><\/p>\n

Under the terms of the plea agreement, Biocompatibles admitted to a misdemeanor charge in connection with the company\u2019s misbranding of LC Bead, in violation of the Food, Drug and Cosmetic Act.<\/span><\/p>\n

LC Bead was cleared by the U.S. Food and Drug Administration as an embolization device that can be placed in blood vessels to block or reduce blood flow to certain types of tumors and arteriovenous malformations. But the device has never been cleared or approved by FDA\u00a0<\/span>as a drug-device combination product or for use as a drug-delivery device or \u201cdrug-eluting\u201d bead.<\/span><\/p>\n

As part of the criminal resolution, Biocompatibles will pay an $8.75 million criminal fine for the misbranding of LC Bead and a criminal forfeiture of $2.25 million.<\/span><\/p>\n

\n

FDA Sought Assurances in 2004<\/span><\/strong><\/p>\n

\n

The FDA sought assurances in 2004 that Biocompatibles would not use FDA clearance for the device for embolization to market the device for drug delivery, according to a statement of offense to which the company agreed.<\/span><\/p>\n

Biocompatibles told the FDA that \u201cunder no circumstance\u201d would the company use the embolization clearance to market the device for drug delivery.<\/span><\/p>\n

However, two years later, Biocompatibles began marketing LC Bead for drug delivery through the company it hired to carry out its sales and distribution in the United States.<\/span><\/p>\n

According to the statement of offense, the distribution company told its sales representatives that LC Bead was \u201c[a] drug-delivery device\u201d and trained its sales representatives to \u201caggressively penetrate the chemoembolization market.\u201d<\/span><\/p>\n

Sales representatives subsequently told health care providers that the device increased the level of chemotherapy delivered to a liver tumor and resulted in \u201cbetter tumor response rates,\u201d despite the lack of FDA clearance or approval for that use and despite the absence at that time of statistically significant evidence to support such claims.<\/span><\/p>\n

\u00a0\u201cThis company is being held criminally and civilly responsible for misbranding a medical device and marketing it for the treatment of seriously ill cancer patients,\u201d said U.S. Attorney Channing D. Phillips for the District of Columbia.<\/strong> \u201cWorking with the FDA and other law enforcement partners, we are committed to holding companies accountable for violating the integrity of the FDA approval process.\u201d<\/span><\/p>\n

In addition, Biocompatibles will pay $25 million to resolve civil allegations under the False Claims Act that the company caused false claims to be submitted to government healthcare programs for procedures in which LC Bead was loaded with chemotherapy drugs and used as a drug-delivery device.<\/span><\/p>\n

When LC Bead was combined with prescription drugs for use as a drug-eluting bead, it constituted a new combination drug-device product that was not approved or cleared by the FDA and not covered by Medicare and other federal health care programs.<\/span><\/p>\n

The federal share of the civil settlement is approximately $23.6 million, and the state Medicaid share of the civil settlement is approximately $1.4 million.<\/span><\/p>\n

Except for the conduct admitted in connection with the criminal plea, the claims resolved by the civil settlement are allegations only, and there has been no determination of liability.<\/span><\/p>\n

\n

LC Bead Entered U.S. Market in 2005<\/span><\/strong><\/p>\n

\n

As part of the civil settlement, the government alleged that when LC Bead entered the U.S. market in 2005, Biocompatibles intended for LC Bead to be used as a drug-delivery device in combination with chemotherapy drugs, despite the lack of FDA approval as a drug-device combination product.<\/span><\/p>\n

\"fda\"In December 2009, Biocompatibles filed an application with FDA for approval of LC Bead as a drug-eluting bead combination product.<\/span><\/p>\n

However, FDA informed the company that it was not accepting the application because clinical studies did not provide adequate evidence of a therapeutic benefit.<\/span><\/p>\n

Nonetheless, Biocompatibles\u2019 distributor routinely advised healthcare providers that LC Bead provided \u201cbetter\u201d or \u201csuperior\u201d therapy for certain types of cancer when, in fact, there was insufficient clinical evidence to support these claims.<\/span><\/p>\n

\u201cThe FDA plays a fundamental role in ensuring the safety and efficacy of medical devices and drugs in this country,\u201d said U.S. Attorney Richard L. Durbin Jr. \u201cThe FDA approval process and clinical studies serve to ensure that patients receive devices that meet those standards.\u00a0 We will vigorously pursue those who ignore or seek to circumvent these important patient protections.\u201d<\/span><\/p>\n

\u201cU.S. consumers rely on the FDA to ensure that there is a reasonable assurance of safety and effectiveness for the approved uses of medical devices,\u201d said Director George M. Karavetsos of FDA Office of Criminal Investigations. \u201cWhen manufacturers ignore FDA\u2019s regulatory authority, they undermine these important assurances.\u201d<\/span><\/p>\n

\n

CASE RESOLVES WHISTLEBLOWER LAWSUIT<\/strong><\/p>\n

\n

The civil settlement with Biocompatibles resolves a lawsuit filed under the whistleblower provision of the False Claims Act, which permits private parties to file suit on behalf of the United States for false claims and share in a portion of the government\u2019s recovery.<\/span><\/p>\n

The civil lawsuit was filed in the Western District of Texas and is captioned United States ex rel. Ryan Bliss v. Biocompatibles, Inc., et al.\u00a0 <\/span><\/p>\n

As part of today\u2019s resolution, Bliss will receive approximately $5.1 million from the civil settlement.<\/span><\/p>\n

\n

BILLIONS RECOVERED UNDER FALSE CLAIMS ACT<\/strong><\/p>\n

\n

Since January 2009, the Justice Department has recovered a total of more than $31.6 billion through False Claims Act cases, with more than $19.2 billion of that amount recovered in cases involving fraud against federal health care programs.<\/span><\/p>\n

\n

**The settlement with Biocompatibles was the result of a coordinated effort among the U.S. Attorney\u2019s Offices for the District of Columbia and the Western District of Texas, and the Civil Division\u2019s Consumer Protection Branch and Commercial Litigation Branch, with assistance from the FDA\u2019s Office of Chief Counsel, HHS\u2019 Office of Counsel to the Inspector General and the Department of Defense\u2019s Defense Criminal Investigative Service.\u00a0 <\/span><\/p>\n

The criminal investigation was conducted by the FDA\u2019s Office of Criminal Investigations.<\/span><\/p>\n

\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

WASHINGTON D.C. A Pennsylvania-based medical device manufacturer Biocompatibles Inc., a subsidiary of BTG plc, plead guilty Monday to misbranding its embolic device LC Bead, federal authorities announced. Biocompatibles will pay more than…<\/p>\n","protected":false},"author":1,"featured_media":27808,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,3],"tags":[3149,3148,1383],"class_list":["post-27806","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home-main-slider","category-u-s-department-of-justice","tag-biocompatibles","tag-btg","tag-fda"],"yoast_head":"\nMedical Manufacturer Pays $36 Million for Misbranding Tumor Device<\/title>\n<meta name=\"description\" content=\"WASHINGTON D.C. 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